olympus bx63 light microscope (Olympus)
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olympus bx63 light microscope
Olympus Bx63 Light Microscope, supplied by Olympus, used in various techniques. Bioz Stars score: 99/100, based on 11315 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fluorescence+microscope/BX63+Automated+Fluorescence+Microscope/pmc13692703-92-29-29
Average 99 stars, based on 11315 article reviews
Olympus Bx63 Light Microscope, supplied by Olympus, used in various techniques. Bioz Stars score: 99/100, based on 11315 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fluorescence+microscope/BX63+Automated+Fluorescence+Microscope/pmc13692703-92-29-29
Average 99 stars, based on 11315 article reviews
olympus bx63 light microscope - by Bioz Stars,
2026-11
99/100 stars
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Fluorescence:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. Microscopy:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. Staining:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. Imaging:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. Saline:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. Incubation:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. Analysis:Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: Images were captured by Article Title: A Photocurable Hydrogel Cardiac Patch Incorporating Formononetin-Loaded Lipid Nanoparticles for Myocardial Repair After Acute Ischemia. Article Snippet: Myocardial infarction (MI) induces ventricular dysfunction through ischemic necrosis and fibrotic remodeling, progressing to heart failure and constituting a major global cardiovascular burden.. To address this, we developed a photocurable, hydrogel-based cardiac patch (Gel-CS/FMN@LNP hydrogel) with favorable mechanical robustness.. The patch is composed of methacryloylated carboxymethyl chitosan (CACSMA) and methacryloylated gelatin (GelMA), incorporating Formononetinloaded lipid nanoparticles (FMN@LNPs) for myocardial restoration. Article Title: Graph attention network-driven single-cell omics analysis reveals how B4GALNT1-mediated glycosylation remodelling of the ferroptosis-pyroptosis network promotes drug resistance in hepatocellular carcinoma. Article Snippet: Additionally, for morphological visualisation, cells were seeded onto coverslips in 24-well plates and stained with Annexin V-FITC/PI as described above, and then imaging using a Article Title: Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. Article Snippet: Cells were then stained with 0.2-μM Calcein AM, cell-permeant green dye (Invitrogen, Cat# C3100MP) and 0.2-μM ethidium homodimer-1 (Invitrogen, Cat# E1169) at 37 C for 10 min. Fluorescence images were acquired using an Olympus IX-83 inverted Article Title: A dual-limitation mechanism governs ethylamine supply for theanine biosynthesis in tea plants. Article Snippet: L-Theanine is a characteristic non-proteinogenic amino acid in tea plants (Camellia sinensis) that determines tea quality.. Its biosynthesis depends on ethylamine supply, but the specific source of ethylamine and the fine regulatory mechanisms remain unclear.. In this study, we integrated short-term low-sugar treatments (stLS), virus-induced gene silencing (VIGS), transient expression in tobacco, genetic transformation of tea callus, and subcellular localization analyses to investigate the regulatory roles of alanine supply, alanine decarboxylase (CsAlaDC), and S-adenosylmethionine decarboxylase (CsSAMDC). Article Title: NEK2 promotes trastuzumab resistance in gastric cancer through WTAP/YTHDF1-dependent m6A regulation of FN1. Article Snippet: 1 Department of Gastroenterology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China 2 Gastrointestinal Surgery, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China Abstract Background Trastuzumab resistance remains a major challenge in the clinical management of gastric cancer (GC), and effective strategies to overcome resistance are still limited.. NEK2 has been implicated in GC progression and therapeutic resistance in several tumor types; however, its role in trastuzumab resistance in GC and the underlying mechanisms remain unclear.. Methods and Results Trastuzumab-resistant NCI-N87/TR cells were established from parental NCI-N87 cells by stepwise exposure to increasing concentrations of trastuzumab. Article Title: A TRIM15-CDX2 loop drives bile acid-induced gastric intestinal metaplasia. Article Snippet: A Article Title: Effects of pyridaben on the spleen and T lymphocytes and intervention strategy in grass carp (Ctenopharyngodon idella). Article Snippet: The widespread use of pyridaben (PDB) poses serious threat to aquatic organism health.. 6-Gingerol, a bioactive component of ginger, has been demonstrated to possess both antioxidant and immunomodulatory properties.. However, the effects of spleen injury of PDB in aquatic species and the potential mitigating effects of 6-Gingerol remain insufficiently characterized. |